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Bispecific antibodies were constructed using genetically encoded unnatural amino acids with orthogonal chemical reactivity. A two-step process afforded homogeneous products in excellent yield. Using this approach, we synthesized an anti-HER2/anti-CD3 bispecific antibody, which efficiently cross-linked HER2+ cells and CD3+ cells. In vitro effector-cell mediated cytotoxicity was observed at picomolar concentrations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299457 | PMC |
| http://dx.doi.org/10.1021/ja303904e | DOI Listing |
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