Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
It is still essential to search for new, available food ingredients with bifidogenic effect, to study their safety, efficacy and production effectiveness upon the creation of functional foods. The review considers protein products such as collagens and their hydrolyzates, which are used in culture mediums as growth factor. They are treated, besides carbohydrate prebiotics, as potential bifidogenic nutrients. Collagen hydralyzates contain all amino acids, required for bifidobacteria growth. That is why it is considered essential to provide control over its biosafety. However, recyclable materials of animal origin are included into a list of Specific Risk Materials of prion disease agents transmitting. Collagen hydralyzates are preserved up to distal intestine parts. This fact approximates their qualities to oligosaccharids' type of prebiotic food fibers, related to the lack of absorption and hydrolytic stability. The additional study of mechanisms of bifidobacteria's forcing is required. It can be made at the expense of the modification of the albuminous cell metabolism during the collagen hydralyzats' unilization.
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