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Synthesis and evaluation of new polyenic compounds as potential PPARs modulators. | LitMetric

Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.

Org Biomol Chem

Laboratoire de Chimie Organique, ESPCI Paris Tech, CNRS, 10 rue Vauquelin, 75231-PARIS Cedex 05, France.

Published: August 2012

AI Article Synopsis

Article Abstract

In order to identify new leads for the treatment of type 2 diabetes, polyenic molecules A and B derived from nipecotic acid and dienol derivatives C have been prepared and their effect on PPARs transcriptional activity evaluated and compared to that of rosiglitazone, WY14,643 and GW501516. Among the synthesized compounds, dienol 39 is the most active, increasing WY14,643 PPARα response and demonstrating partial agonist properties on rosiglitazone PPARγ.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2ob25593fDOI Listing

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