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Reconfiguration of brain network dynamics in bipolar disorder: a hidden Markov model approach.
Transl Psychiatry
December 2024
School of Computer Science and Technology (School of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China.
Bipolar disorder (BD) is a neuropsychiatric disorder characterized by severe disturbance and fluctuation in mood. Dynamic functional connectivity (dFC) has the potential to more accurately capture the evolving processes of emotion and cognition in BD. Nevertheless, prior investigations of dFC typically centered on larger time scales, limiting the sensitivity to transient changes.
View Article and Find Full Text PDFApplications of Transformers in Computational Chemistry: Recent Progress and Prospects.
J Phys Chem Lett
December 2024
Macao Institute of Materials Science and Engineering, Faculty of Innovation Engineering, Macau University of Science and Technology, Taipa, Macau SAR 999078, China.
The powerful data processing and pattern recognition capabilities of machine learning (ML) technology have provided technical support for the innovation in computational chemistry. Compared with traditional ML and deep learning (DL) techniques, transformers possess fine-grained feature-capturing abilities, which are able to efficiently and accurately model the dependencies of long-sequence data, simulate complex and diverse chemical spaces, and explore the computational logic behind the data. In this Perspective, we provide an overview of the application of transformer models in computational chemistry.
View Article and Find Full Text PDFProfessionals' Perspectives of Smart Stationary Bikes in Rehabilitation: Qualitative Study.
JMIR Rehabil Assist Technol
December 2024
Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain (CRIR) - Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM) du Centre intégré universitaire de santé et de services sociaux du Centre-Sud-de-l'Île-de-Montréal (CCSMTL), Université de Montréal, Institut de Réadaptation Gingras Lindsay de Montréal, 6300 avenue de Darlington, Montréal, QC, H3S 2J4, Canada, 1 514-343-6111.
Background: Stationary bikes are used in numerous rehabilitation settings, with most offering limited functionalities and types of training. Smart technologies, such as artificial intelligence and robotics, bring new possibilities to achieve rehabilitation goals. However, it is important that these technologies meet the needs of users in order to improve their adoption in current practice.
View Article and Find Full Text PDFA Socioecological Approach to Support the Transition to Adult Care for Youth With Medical Complexity: Family Perspectives and Recommendations.
Health Expect
February 2025
School of Nursing, McMaster University, Hamilton, Ontario, Canada.
Introduction: The transition from paediatric to adult health care (i.e., 'health care transition') poses many challenges for youth with medical complexity (YMC) and their families.
View Article and Find Full Text PDFUpdated cost-effectiveness analysis of tislelizumab in combination with chemotherapy for the first-line treatment of advanced gastric cancer or gastroesophageal junction adenocarcinoma.
Front Oncol
December 2024
Department of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Objective: The RATIONALE-305 trial demonstrated that tislelizumab in combination with chemotherapy regimens was more beneficial than chemotherapy regimens alone in the treatment of patients with advanced gastric cancer or gastroesophageal junction adenocarcinoma (GC/GEJC). This study aimed to evaluate the cost-effectiveness of tislelizumab combination chemotherapy in the treatment of advanced GC/GEJC from the perspective of the Chinese health service system.
Methods: A three-state partition survival model was constructed to evaluate the economics of tislelizumab combined with chemotherapy as the first-line treatment of advanced GC/GEJC.
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