Live imaging kidney development in zebrafish.

Methods Mol Biol

Nephrology Division and Department of Pathology, Charlestown, MA, USA.

Published: September 2012

AI Article Synopsis

  • The zebrafish is an effective model for studying organ development and regeneration due to its transparency during embryonic stages, allowing for easy observation of organ formation.
  • The embryos are easily manipulated through surgical, genetic, or chemical methods, enhancing experimental flexibility.
  • Findings from zebrafish studies, particularly on nephron development, are relevant to human kidney research because of the strong conservation of these structures among vertebrates.

Article Abstract

The zebrafish has emerged as a powerful model to study organ development and regeneration. It has a number of advantages over other vertebrate model systems. The embryo can be kept transparent throughout embryonic development, which allows direct visualization of the developing organs. In addition, embryos can be easily manipulated surgically, genetically, or chemically. Furthermore, because nephron shape and function are remarkably conserved among vertebrates, zebrafish findings can directly inform human studies. Here, we describe a simple procedure that can be used by laboratories to investigate the development of zebrafish kidney and other organs by time-lapse microscopy.

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Source
http://dx.doi.org/10.1007/978-1-61779-851-1_6DOI Listing

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