Animal models for vaccine therapy.

Animal models are important for defining paradigms of tumor immunology and for evaluating therapeutic efficacy of immunotherapy. Many animal models have been used for evaluating in vivo characteristics of malignant gliomas and their responses to therapy. No animal model, however, is perfect because malignant glioma has a very heterogeneous biological behavior. There are so many parallels between mouse and human immunology, but there are significant discrepancies in immune system. Animal models for vaccine therapy can be classified as transplantable tumor models and models of spontaneous tumor in genetically engineered animals. Although transplantable tumor models have been used to test immunotherapeutic efficacy and remain a mainstay in study of brain tumor immunology, a lot of tumor vaccines that look promising in experimental animals have turned out to be ineffective clinically. Recent advances of laboratory techniques and understanding of genetic and molecular characteristics of gliomas allows for animal models of gliomas with similar biologic characteristics. Well-designed glioma models that accurately reflect the biology, pathology and clinical behaviors of human gliomas can provide more useful preclinical informations to predict clinical efficacy of novel immunotherapies and cancer vaccines.