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A local redox cycling-based electrochemical chip device with nanocavities for multi-electrochemical evaluation of embryoid bodies.
Lab Chip
December 2015
Graduate School of Environmental Studies, Tohoku University, Japan. and WPI-Advanced Institute for Materials Research, Tohoku University, Japan.
An electrochemical device, which consists of electrode arrays, nanocavities, and microwells, was developed for multi-electrochemical detection with high sensitivity. A local redox cycling-based electrochemical (LRC-EC) system was used for multi-electrochemical detection and signal amplification. The LRC-EC system consists of n(2) sensors with only 2n bonding pads for external connection.
View Article and Find Full Text PDFDensified electrochemical sensors based on local redox cycling between vertically separated electrodes in substrate generation/chip collection and extended feedback modes.
Anal Chem
April 2014
Graduate School of Environmental Studies and §WPI Advanced Institute for Materials Research, Tohoku University, Sendai, Japan 980-8579.
A new local redox cycling-based electrochemical (LRC-EC) device integrated with many electrochemical sensors has been developed into a small chip device. The LRC-EC chip device was successfully applied for detection of alkaline phosphatase and horseradish peroxidase activity in substrate generation/chip collection (SG/CC) and extended feedback modes, respectively. The new imaging approach with extended feedback mode was particularly effective for sharpening of the image, because this mode uses feedback signals and minimizes the undesired influence of diffusion.
View Article and Find Full Text PDFDroplet array on local redox cycling-based electrochemical (LRC-EC) chip device.
Lab Chip
February 2014
Graduate School of Environmental Studies, Tohoku University, Japan.
We have previously reported a local redox cycling-based electrochemical (LRC-EC) system for the incorporation of many electrochemical sensors into a small chip device. In the present study, a new type of LRC-EC chip device was fabricated for the detection of a droplet array. To detect electrochemically redox compounds in droplets, Pt pseudo-reference/counter electrodes were incorporated into the individual sensors of the LRC-EC chip device.
View Article and Find Full Text PDFBioimaging with micro/nanoelectrode systems.
Anal Sci
September 2013
WPI-Advanced Institute for Materials Research, Tohoku University, Sendai, Japan.
This article presents an overview of the recent progress made by our group in the development of bioelectrochemical imaging devices and systems with micro/nanoelectrodes. The topics include bioimaging of enzymes and live cells by scanning electrochemical microscopy (SECM), high-resolution bioimaging by SECM equipped with a nanoprobe, comprehensive measurements and bioimaging with local-redox cycling-based electrochemical (LRC-EC) devices, and rapid and sensitive bioimaging with BioLSI.
View Article and Find Full Text PDFAccumulation and detection of secreted proteins from single cells for reporter gene assays using a local redox cycling-based electrochemical (LRC-EC) chip device.
Lab Chip
November 2012
Graduate School for Environmental Studies, Tohoku University, 6-6-11, Aramaki, Aoba, Sendai 980-8579, Japan.
A lab-on-a-chip device is described for the electrochemical detection of alkaline phosphatase (ALP) secreted by transformed single HeLa cells. Detection on the chip device is based on local redox cycling at 256 individually addressable sensor points. Ring-disk electrodes (generator/collector) are arranged at individual sensor points to amplify the signal due to redox-cycling with only 32 connector pads.
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