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While the genetic paradigm of cancer etiology has proven powerful, it remains incomplete as evidenced by the widening spectrum of non-cancer cell-autonomous "hallmarks" of cancer. Studies have demonstrated the commonplace presence of high oncogenic mutational burdens in homeostatically-stable epithelia. Hence, the presence of driver mutations alone does not result in cancer.
View Article and Find Full Text PDFPre-operative ultrasound localization of misdiagnosed foreign object as verruca vulgaris: a case report.
J Dermatolog Treat
December 2025
Department of Dermatology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, P.R. China.
Aim: Verruca vulgaris is a common skin disease among children. Foreign object mimicking a wart is unusual.
Methods: A report of a 6-year-old boy with foreign object misdiagnosed as verruca vulgaris.
Rare Cutaneous Primary Presentation of Extracavitary Primary Effusion Lymphoma.
Am J Dermatopathol
January 2025
Department of Dermatology, Columbia University Medical Center, New York, NY; and.
Primary effusion lymphoma (PEL) is a rare and aggressive B-cell lymphoma typically associated with human herpesvirus 8 (HHV-8) and Epstein-Barr virus infections. It classically presents as a malignant effusion in body cavities, but rarely presents with an extracavitary variant characterized by solid tumors in lymph nodes or extranodal sites such as the gastrointestinal tract, skin, lungs, and nervous system. This case report describes an unusual presentation of primary cutaneous extracavitary PEL in an HIV-positive patient that has only been reported in 8 cases previously.
View Article and Find Full Text PDFA Case of Leukemia Cutis (Acute Myeloid Leukemia) With Epidermotropism.
Am J Dermatopathol
December 2024
Department of Dermatology, Columbia University, New York, NY.
Acute myeloid leukemia is a cancer involving uncontrolled proliferation of hematopoietic cells. Cutaneous involvement is referred to as leukemia cutis (LC). The histopathologic presentation of LC is variable, and may present with perivascular, periadnexal, dermal, or subcutaneous infiltrate.
View Article and Find Full Text PDFAn Unusual Presentation of Plantar Psoriasis: A Case Report.
Cureus
November 2024
Family Medicine, Unidade de Saúde Familiar, Unidade Local de Saúde de Braga, Braga, PRT.
Plantar psoriasis is a chronic inflammatory skin disorder, typically characterized by erythematous plaques with thick silvery scales localized on the soles. This condition can significantly impair patients' quality of life, particularly through pain and mobility challenges. It is considered a subtype of plaque psoriasis but presents unique diagnostic and therapeutic challenges due to its specific location.
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