AI Article Synopsis
- Limited data on how current pesticides affect non-target organisms like fish, particularly regarding their cytotoxicity and immunotoxicity.
- An experiment was conducted exposing rainbow trout lymphocytes to pesticides atrazine, permethrin, and piperonyl butoxide (PBO) to assess their effects on viability and proliferation.
- Results showed that these chemicals reduced lymphocyte viability and proliferation at higher concentrations, urging further research to understand the implications in real-life scenarios.
Article Abstract
For many current use pesticides, limited information exists on their cytotoxicity and immunotoxicity in non-target organisms such as fish. We examined the effects of atrazine, permethrin and piperonyl butoxide (PBO) exposure, in vitro, on rainbow trout (Oncorhynchus mykiss) lymphocyte viability and proliferation. Purified rainbow trout peripheral blood leukocytes (PBLs) were exposed in vitro to the test chemicals (0, 0.01, 0.1, 1 and 10 μM) for 96 h, with and without the mitogen lipopolysaccharide. All three chemicals caused a decrease in both lymphocyte viability and proliferation at 10 μM, while atrazine also suppressed proliferation of PBLs at 1 μM. The in vitro toxicity of these chemicals to this salmonid underscores the need for further investigation using in vivo studies and host resistance models.
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| http://dx.doi.org/10.1016/j.fsi.2012.05.020 | DOI Listing |
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