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Objective: To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture.
Design: Retrospective, observational, cohort study.
Setting: Private IVF center.
Patient(s): A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles.
Intervention(s): None.
Main Outcome Measure(s): Live birth rate.
Result(s): Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥ 2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels <1.5 ng/mL (24.6%) and 1.5-1.99 ng/mL (26.7%). No such significant differences in live birth rates in cycles with GnRH antagonist could be observed.
Conclusion(s): A rise of serum P levels ≥ 2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET.
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| http://dx.doi.org/10.1016/j.fertnstert.2012.04.041 | DOI Listing |
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