Objectives: (1) To develop a prototype Continuity of Care Record (CCR) with context-specific links to electronic HIV information resources; and (2) to assess case managers' perceptions regarding the usability of the prototype.
Methods: We integrated context-specific links to HIV case management information resources into a prototype CCR using the Infobutton Manager and Librarian Infobutton Tailoring Environment (LITE). Case managers (N=9) completed a think-aloud protocol and the Computer System Usability Questionnaire (CSUQ) to evaluate the usability of the prototype. Verbalizations from the think-aloud protocol were summarized using thematic analysis. CSUQ data were analyzed with descriptive statistics.
Results: Although participants expressed positive comments regarding the usability of the prototype, the think-aloud protocol also identified the need for improvement in resource labels and for additional resources. On a scale ranging from 1 (strongly agree) to 7 (strongly disagree), the average CSUQ overall satisfaction was 2.25 indicating that users (n=9) were generally satisfied with the system. Mean CSUQ factor scores were: System Usefulness (M=2.13), Information Quality (M=2.46), and Interface Quality (M=2.26).
Conclusion: Our novel application of the Infobutton Manager and LITE in the context of case management for persons living with HIV in community-based settings resulted in a prototype CCR with infobuttons that met the majority of case managers' information needs and received relatively positive usability ratings. Findings from this study inform future integration of context-specific links into CCRs and electronic health records and support their use for meeting end-users information needs.
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http://dx.doi.org/10.1016/j.ijmedinf.2012.05.002 | DOI Listing |
Sex Reprod Health Matters
January 2025
Associate Professor, Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Associate Professor, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
We investigated the association between values and attitudes toward sexual and reproductive health and rights (SRHR) and gender equality, with reproductive agency in Ethiopia, Kenya, and Zimbabwe. Using 2020-21 World Values Survey (WVS) data (n = 3,096), we utilized the SRHR Support Index including five subindices to gauge SRHR attitudes, the WVS Equality Index for gender equality values, and the perceived level of freedom of choice and control over whether, when, and how many children to have as a proxy for reproductive agency. Descriptive statistics, bivariate, and multivariable logistic regressions were used to analyse how values and attitudes differed between respondents of high vs low reproductive agency using the median as cutoff, stratified by country and sex.
View Article and Find Full Text PDFmSystems
December 2024
Department of Computational Biology, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Sochi, Russia.
Unlabelled: Context-specific genome-scale model (CS-GSM) reconstruction is becoming an efficient strategy for integrating and cross-comparing experimental multi-scale data to explore the relationship between cellular genotypes, facilitating fundamental or applied research discoveries. However, the application of CS modeling for non-conventional microbes is still challenging. Here, we present a graphical user interface that integrates COBRApy, EscherPy, and RIPTiDe, Python-based tools within the BioUML platform, and streamlines the reconstruction and interrogation of the CS genome-scale metabolic frameworks via Jupyter Notebook.
View Article and Find Full Text PDFBMC Genomics
December 2024
Philipps University of Marburg, Center for Human Genetics, Marburg, Germany.
Background: Genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation (called exposure eQTL (eQTL)) it is possible to identify context specific gene regulatory variants and connect them to oncological diseases based on genome-wide association studies (GWAS).
Results: We isolate CD8 T cells from 461 healthy donors and stimulate them with high doses of 5 different carcinogens to identify regulatory mechanisms of DNA damage-induced apoptosis.
ArXiv
October 2024
Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
J Rehabil Med
November 2024
Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden; Danderyd University Hospital, Department of Medical Specialities, Stockholm, Sweden.
Objective: This study explores the effectiveness of using the International Classification of Functioning, Disability and Health (ICF) as a coding framework to document work-related disability information in sick leave certificates, focusing on depression and fibromyalgia in Sweden.
Design: A qualitative ICF linking study was conducted, mapping information from 200 certificates per diagnosis to ICF.
Methods: ICF linking rules were followed strictly.
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