AI Article Synopsis
- The study found that continual exposure to Gram-negative bacteria led to earlier stroke onset in stroke-prone hypertensive rats compared to controls.
- During stroke onset, observable symptoms like hindlimb paralysis and changes in movement were present in the infected rats but not in the controls.
- Increased levels of certain biomarkers in the infected rats indicated that oxidative stress responses from bacterial components likely contributed to the accelerated stroke onset.
Article Abstract
This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in stroke-prone spontaneously hypertensive rats (SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides (LPSs) than in uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in LPS-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, thiobarbituric acid reactive substance, and 8-hydroxydeoxyguanosine increased in LPS-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from LPSs.
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| http://dx.doi.org/10.3109/10641963.2012.689042 | DOI Listing |
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