For the first time the relationship between mutations in the pancreatic secretory trypsin inhibitor (SPINK1) in humans and the development of chronic pancreatitis was established in 2000. By mid 2011 the number of studies on the influence of SPINK1 gene mutations on the development of pancreatitis exceeds 250, the results vary greatly. According to modern concepts, mutations in SPINK1 gene are associated with the development of both acute and chronic pancreatitis, and are defined in all etiological forms. Literature review shows the data of the most significant studies about the role of SPINK1 gene mutations in pancreatic diseases.
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