Aim: To assess transesophageal ultrasonography capabilities in diagnosis of mediastinal malignant tumors.
Materials And Methods: Technique of radial transesophageal ultrasonography was used to diagnose mediastinal malignancy in 157 patients. Method of amplitude hystography was employed to assess lymph nodes. In 84 cases diagnosis had histological confirmation.
Results: In 61 case out of 84 (73%) diagnosis was true. In of lymph nodes without primary tumor in the lung diagnosis was true in 72% (26 cases out of 36) and with primary tumor in 73% (35 cases out of 48). Assessment of lymph nodes sized 30 mm and more was correct in 92% (11 cases out of 12) and much higher than for lymph nodes sized less 30 mm in diameter (69%, 50 out of 72 [p < 0.001, chi2]). Correct diagnosis for lymph nodes less than 10 mm in diameter was achieved in 65% (13 out of 20) [p = 0.44, chi2], for diameter 10-20 mm accuracy was 71% (22 cases out of 31) [p = 0.96, chi2] and similar to the one for diameter 20-30 mm assessment. Location of lesion proved to be important. For lymph nodes of 3, 7, 8, 9 zones (ATS classification) precision was much higher than for other locations. There were no adverse events during the study.
Conclusion: Transesophageal ultrasonography with the use electronic radial detector is effective an safe method of mediastinal lymph nodes and primary tumors assessment.
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PLoS Pathog
January 2025
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
SARS-CoV-2 continues to transmit and evolve in humans and animals. White-tailed deer (Odocoileus virginianus) have been previously identified as a zoonotic reservoir for SARS-CoV-2 with high rates of infection and probable spillback into humans. Here we report sampling 1,127 white-tailed deer (WTD) in Pennsylvania, and a genomic analysis of viral dynamics spanning 1,017 days between April 2021 and January 2024.
View Article and Find Full Text PDFCancer Rep (Hoboken)
January 2025
Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, People's Republic of China.
Background: Neuroendocrine tumors of the thymus (NETT) are rare and malignant tumors that arise in the anterior mediastinum. These tumors can exhibit aggressive behavior and may involve surrounding critical structures, such as the superior vena cava. This case contributes to the literature by presenting a recurrent thymic carcinoma with invasion of major blood vessels, including the superior vena cava, and the complexities involved in its surgical management.
View Article and Find Full Text PDFJ Gynecol Oncol
January 2025
Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Objective: To evaluate upstaging, lymph node (LN) metastasis, and recurrence in patients with presumed stage I endometrial cancer using preoperative magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT).
Methods: Retrospective review of 422 patients with presumed clinical stage I endometrial cancer diagnosed via MRI and PET-CT (July 2014-June 2023). Surgical staging included pelvic lymph nodes (PLNs) and para-aortic lymph nodes (PALNs), classifying patients as low/intermediate- or high-risk groups.
Vet Sci
December 2024
Laboratoire d'Exploration et Valorisation des Écosystèmes Steppiques, Faculty of Natural and Life Sciences, University of Djelfa, PO Box 3117, Djelfa 17000, Algeria.
Toxoplasmosis is a major veterinary and public health issue affecting humans and animals, where felids represent the definitive hosts of the causative agent . While the infections are mostly asymptomatic, the disease could be severe in immune-compromised patients and pregnant women. This study was conducted to evaluate the level of knowledge, practice, and attitude toward this disease among a sample of Algerian women.
View Article and Find Full Text PDFVaccines (Basel)
January 2025
Laboratory of Immunopathology, Butantan Institute, São Paulo 05585-000, Brazil.
: Cationic polymers were shown to assemble with negatively charged proteins yielding nanoparticles (NPs). Poly-diallyl-dimethyl-ammonium chloride (PDDA) combined with ovalbumin (OVA) yielded a stable colloidal dispersion (OVA/PDDA-NPs) eliciting significant anti-OVA immune response. Dendritic cells (DCs), as sentinels of foreign antigens, exert a crucial role in the antigen-specific immune response.
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