Assessment of molecular interactions through magnetic relaxation.

Angew Chem Int Ed Engl

Nanoscience Technology Center, Department of Chemistry, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.

Published: July 2012

The dissociation constant (K) of various molecular interactions was determined using a novel competition assay with binding magnetic relaxation nanosensors (bMRs). In this assay, changes in the magnetic relaxation of an aqueous suspension of the nanosensors facilitate the fast determination of K values using nanomolar protein concentrations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461998PMC
http://dx.doi.org/10.1002/anie.201202077DOI Listing

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