AI Article Synopsis
Article Abstract
Alginates from seaweed are used in chronic wound management, though the molecular and cellular effects of various alginate dressings are not well documented. We have developed ultrapure sodium-alginates from Pseudomonas fluorescens with different content and distribution of single guluronic acid (G) residues (0-45% G), and tested their biological activities on human primary keratinocytes (KCs). The alginates inhibited KC migration and induced expression of differentiation markers. The potency of the alginates correlated with the increasing percentage of single G residues. These findings were explained by different binding and release of ionic calcium (Ca++) from the alginates which subsequently triggered differentiation. Ca-free alginates had no effect on KC migration and differentiation, but the chemokine receptor CXCR7 was upregulated. Q-PCR revealed that also CXCL12/SDF-1, one of two known CXCR7-ligands, was induced by the alginates. Both CXCR7 and CXCL12-induction was dependent on the alginate G-content, and highest upregulation was induced by an alginate with 19% single G residues. In the epidermis, CXCR7 expression was restricted to the basal layer. This study defines two biological effects of ultrapure alginates on KCs, both being dependent on the alginate structure, and being either dependent or independent of Ca.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jbm.a.34219 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advanced Bionic 3D Interfacial Solar Steam Generator With One-way Water Supply for Highly Efficient Desalination and Oil-Fouling Prevention.
Adv Sci (Weinh)
December 2024
Institute for Frontier Materials, Deakin University, Geelong, VIC, 3216, Australia.
Interfacial solar steam generation (ISSG) employed for seawater desalination and wastewater purification shows great promise to alleviate global freshwater scarcity. However, simultaneous optimization of water transfer direction in a cost-effective and reliable ISSG to balance thermal localization, salt accumulation, and resistance to oilfouling represents a rare feat. Herein, inspired by seabird beaks for unidirectional water transfer, eco-friendly and cost-effective plant extracts, sodium alginate, and tannic acid, are selected for crafting an innovative Sodium Alginate-Tannic Acid Hemispheric Evaporator (STHE).
View Article and Find Full Text PDFsynthesis of gold nanoparticles embedded in a magnetic nanocomposite of glucosamine/alginate for enhancing recyclable catalysis performance of nitrophenol reduction.
Nanoscale Adv
December 2024
Institute of Chemical Technology, Vietnam Academy of Science and Technology 1A TL29 Street, District 12 Ho Chi Minh City 700000 Vietnam
In this study, we introduce an synthesis technique for incorporating gold nanoparticles (AuNPs) into a magnetic nanocomposite made of glucosamine and alginate (GluN/Alg) ionotropic gelation. GluN acted as a reducing agent for gold ions, leading to the formation of AuNPs which embedded in the nanocomposite FeO@GluN/Alg. Analytical techniques confirmed the crystallite structure of the nanocomposite AuNPs/FeO@GluN/Alg, which had an average size of 30-40 nm.
View Article and Find Full Text PDFWhere do the pyrene molecules reside within the surface active ionic liquid micelles in presence of sodium alginate?
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Chemistry, Presidency University, Kolkata 700073, India. Electronic address:
Pyrene fluorescence in aqueous solutions of two surface active ionic liquids, namely, 1-decyl-3-methylimidazolium chloride, and 1-hexadecyl-3-methylimidazolium chloride was investigated in presence of a biopolymer sodium alginate. The principal objective of this study was to explore the influence of the length of the hydrocarbon tails of these surface active ionic liquids on the possible location of the probe (pyrene) molecules in presence of the additive. While an abrupt decrease in the values of the ratio of the intensity of the first vibronic band to that of the third band of pyrene emission spectrum with concentration was observed for 1-hexadecyl-3-methylimidazolium chloride in presence of sodium alginate like the polymer-free case reported earlier, there was a peculiar reversal for 1-decyl-3-methylimidazolium chloride + sodium alginate.
View Article and Find Full Text PDFEuropean clinical practice guideline: managing and treating laryngopharyngeal reflux disease.
Eur Arch Otorhinolaryngol
December 2024
Research Committee of Young-Otolaryngologists of the International Federations of Oto-rhino- laryngological Societies (YO-IFOS), Paris, France.
Objective: To propose a European consensus for managing and treating laryngopharyngeal reflux disease (LPRD) to guide primary care and specialist physicians.
Methods: Twenty-three European experts (otolaryngologists, gastroenterologists, surgeons) participated in a modified Delphi process to revise 38 statements about the definition, clinical management, and treatment of LPRD. Three voting rounds were conducted on a 5-point scale and a consensus was defined a priori as agreement by 80% of the experts.
Optimising topical wound care outcomes for fungating breast wounds - A systematic review of current institutional practice.
Surgeon
December 2024
Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Surgery, Khoo Teck Puat Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University of Singapore, Singapore.
Background: Fungating breast wounds cause significant complications and morbidity to patients. Wound care is of paramount importance in optimising care and alleviating suffering for patients with malignant breast wounds. Currently, routinely implemented objective assessment tools for fungating breast wound treatment outcomes are non-existent, and institutional practice varies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!