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| http://dx.doi.org/10.2337/dc12-0163 | DOI Listing |
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Glycemia reduction in type 2 diabetes-Hypoglycemia outcomes: A randomized clinical trial.
PLoS One
November 2024
Department of Biostatistics and Bioinformatics, Milken Institute of Public Health, The Biostatistics Center, The George Washington University, Rockville, MD, United States of America.
Article Synopsis
- The study aimed to compare the risk of hypoglycemia among type 2 diabetes patients on metformin and adding one of four common therapies: glargine, glimepiride, liraglutide, or sitagliptin.
- The trial included 5,047 participants, assessing severe hypoglycemia events and symptoms over an average of 5 years, with a per-protocol analysis of 4,830 who completed follow-ups.
- Results showed that glimepiride had the highest incidence of severe hypoglycemia (1.3%), while liraglutide and sitagliptin had the lowest risks, indicating varying hypoglycemia likelihood based on the second medication added
A Bayesian method for adverse effects estimation in observational studies with truncation by death.
Stat Methods Med Res
November 2024
Department of Biostatistics, Brown University, Providence, RI, USA.
Death among subjects is common in observational studies evaluating the causal effects of interventions among geriatric or severely ill patients. High mortality rates complicate the comparison of the prevalence of adverse events between interventions. This problem is often referred to as outcome "truncation" by death.
View Article and Find Full Text PDFClinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13.
Endocrine
November 2024
Department of Endocrinology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Purpose: This study aimed to describe the clinical features, diagnostic and therapeutic course of a patient with MODY13 caused by KCNJ11 (c.101G > A, p.R34H) and how it contributes to the pathogenesis of MODY13, and to explore new therapeutic targets.
View Article and Find Full Text PDFIntragenic Agrobacterium-mediated gene transfer mimics micro-translocations without foreign DNA.
Planta
February 2024
AgResearch Ltd, Private Bag 4749, Christchurch, New Zealand.
Agrobacterium-mediated transformation of Nicotiana tabacum, using an intragenic T-DNA region derived entirely from the N. tabacum genome, results in the equivalence of micro-translocations within genomes. Intragenic Agrobacterium-mediated gene transfer was achieved in Nicotiana tabacum using a T-DNA composed entirely of N.
View Article and Find Full Text PDFComparative effects of fixed-dose mitiglinide/voglibose combination and glimepiride on vascular endothelial function and glycemic variability in patients with type 2 diabetes: A randomized controlled trial.
J Diabetes Investig
April 2024
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Article Synopsis
- This study compared the effects of two diabetes medications: mitiglinide/voglibose and glimepiride, on blood sugar levels and blood vessel health in type 2 diabetes patients.
- It was conducted as a multicenter, open-label, randomized crossover trial involving 30 hospitalized patients, measuring outcomes like blood glucose variability and vascular function over a 5-day treatment period for each drug.
- Results showed that while both medications had similar effects on vascular function, mitiglinide/voglibose significantly reduced blood sugar fluctuations and time spent in extreme glucose ranges compared to glimepiride.
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