AI Article Synopsis
- Fourteen cases of ovarian carcinoma (OC) were analyzed for changes in the c-myc and c-Ha-ras-1 oncogenes.
- Four aggressive OC cases showed c-myc amplification, while an increased frequency of c-Ha-ras-1 allele A4 was identified in patients.
- Genetic rearrangements associated with allele A4 were found in all OC samples with this allele, indicating it could serve as a potential genetic marker for OC risk when considered alongside other clinical factors.
Article Abstract
Fourteen cases of the ovarian carcinoma (OC) were studied for alterations of c-myc and c-Ha-ras-1 oncogens. Amplification of c-myc was found in four aggressive and widespread OC. An increased frequency of one of the four common alleles of c-Ha-ras-1-allele A4-was determined in OC patients. Rearrangements of c-Ha-ras-1-allelic deletions and change in the allele fragment length-were found in all OC with A4 allele. In contrast, no alterations were detected in tumours without allele A4. Thus allele A4 of c-Ha-ras-1 may be viewed as a genetic marker of predisposition to OC in combination with other clinical parameters. Alterations of c-myc and c-Ha-ras-1 oncogens were observed in 8 out of 14 OC samples suggesting that the development of this type of human neoplasm is due to rearrangements of these genes.
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