A flexible and divergent synthesis of cryptophycin unit A analogues is described. This method relies on iridium-catalysed stereo- and enantioselective crotylation and chemoselective one-pot oxidative olefination to access common intermediate . Heck, cross metathesis, and Suzuki-Miyaura reactions are illustrated for the generation of methyl ester unit A analogues .
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494784 | PMC |
| http://dx.doi.org/10.1039/c2cc32417b | DOI Listing |
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