The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771315 | PMC |
| http://dx.doi.org/10.1042/BST20120084 | DOI Listing |
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