Two C(18)-diterpenoid alkaloids, puberunine (1) and puberudine (2), together with four other new alkaloids, including the first examples having β-oriented substitution at C-3 and a rare chloro-substituent were isolated from Aconitum barbatum var. puberulum. Their structures were elucidated by spectroscopic methods. Puberunine and puberudine, which possess a unique rearranged E ring and an opened A ring, respectively, represent new subtypes of the C(18)-diterpenoid alkaloids. A plausible biosynthetic pathway of 1 and 2 was proposed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol3008217 | DOI Listing |
Publication Analysis
Top Keywords
puberunine puberudine
12
c18-diterpenoid alkaloids
12
aconitum barbatum
8
barbatum var
8
var puberulum
8
puberudine c18-diterpenoid
4
alkaloids
4
alkaloids aconitum
4
puberulum c18-diterpenoid
4
alkaloids puberunine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!