Two new members of the spirotetronate class, nai414-A and nai414-B, were discovered and isolated from an Actinoallomurus sp. Their structures were established by 1D and 2D NMR, UV, and MS analyses and by chemical degradation. They showed antimicrobial and antitumor activity against Gram-positive bacteria and against human microvascular endothelial cells, respectively. Substituting bromide for chloride ions in the growth medium afforded mono- and dibrominated derivatives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np300003n | DOI Listing |
Publication Analysis
Top Keywords
halogenated spirotetronates
4
spirotetronates actinoallomurus
4
actinoallomurus members
4
members spirotetronate
4
spirotetronate class
4
class nai414-a
4
nai414-a nai414-b
4
nai414-b discovered
4
discovered isolated
4
isolated actinoallomurus
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!