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Cutting-edge tools for unveiling the dynamics of plasmid-host interactions.
Trends Microbiol
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Ineos Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford OX1 3RE, UK. Electronic address:
The plasmid-mediated transfer of antibiotic resistance genes (ARGs) in complex microbiomes presents a significant global health challenge. This review examines recent technological advancements that have enabled us to move beyond the limitations of culture-dependent detection of conjugation and have enhanced our ability to track and understand the movement of ARGs in real-world scenarios. We critically assess the applications of single-cell sequencing, fluorescence-based techniques and advanced high-throughput chromatin conformation capture (Hi-C) approaches in elucidating plasmid-host interactions at unprecedented resolution.
View Article and Find Full Text PDFReal-time deformable structure tracking in 3D ultrasound sequences using deformable convolutional layers.
Comput Biol Med
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University of Lübeck, Ratzeburger Allee 160, Lübeck, 23562, Schleswig-Holstein, Germany. Electronic address:
Ultrasound imaging can provide 3D images of soft tissue structures in real-time without harmful radiation. Due to its high level of availability and low-cost characteristics, it is becoming more and more interesting for therapy guidance purposes like in radiotherapy. However, for usage in radiotherapy a robust and real-time image analysis method is required to be able to track the target during the treatment session.
View Article and Find Full Text PDF"We Want to Well Outlive Us": Behind the Dissemination and Sustainability of in Australia.
Qual Health Res
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Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
is a free, weekly organized mass participation physical activity event providing a remarkable example of at-scale dissemination, with over 1 million participants and 150,000 volunteers in Australia. This qualitative study draws on stakeholders' experiences to explore how succeeded with its dissemination and sustainability in Australia. Maximum variation and snowball sampling methods were used to select interviewees representing three stakeholder groups: Australia employees; volunteer organizers (event directors and ambassadors); and local external stakeholders (e.
View Article and Find Full Text PDFDeepFocus: a transnasal approach for optimized deep brain stimulation of reward circuit nodes.
J Neural Eng
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Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania, 15213-3815, UNITED STATES.
Objective: Transcranial electrical stimulation (TES) is an effective technique to modulate brain activity and treat diseases. However, TES is primarily used to stimulate superficial brain regions and is unable to reach deeper targets. The spread of injected currents in the head is affected by volume conduction and the additional spreading of currents as they move through head layers with different conductivities, as is discussed in [1].
View Article and Find Full Text PDFSingle-molecule microscopy reveals that importin α slides along DNA while transporting cargo molecules.
Biochem Biophys Res Commun
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Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai, 980-8577, Japan; Department of Chemistry, Graduate School of Science, Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai, 980-8577, Japan; Faculty of Engineering and Graduate School of Engineering, Gifu University, Yanagido 1-1, Gifu, 501-1193, Japan. Electronic address:
Importin α is a crucial player in the nucleocytoplasmic transport of nuclear localization signal (NLS)-containing cargo proteins and is suggested to bind to DNA directly. We hypothesized that importin α, after binding to DNA, may move along DNA via sliding or hopping. We investigated the movement dynamics of importin αs fused to AcGFP along DNA using single-molecule fluorescence microscopy and single-tethered DNA arrays.
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