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Brief memory reactivation may not improve visual perception.
Vision Res
January 2025
School of Psychological and Cognitive Sciences, and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China. Electronic address:
Visual perceptual learning often requires a substantial number of trials to observe significant learning effects. Previously Amar-Halpert et al. (2017) have shown that brief reactivation (5 trials/day) is sufficient to improve the performance of the texture discrimination task (TDT), yielding comparable improvements to those achieved through full practice (252 trials/day).
View Article and Find Full Text PDFHeterogeneous mosquito exposure increases and co-infections: a modelling study.
Proc Biol Sci
December 2024
Infectious Disease Epidemiology and Analytics G5 Unit, Institut Pasteur, Université Paris Cité, Paris, France.
In malaria-endemic regions, and coexist and may interact. For instance, fevers induced by might activate dormant parasites and concurrent radical cure of both species has been proposed to prevent relapses. Heterogeneous mosquito exposure may contribute to the dependence of both parasites.
View Article and Find Full Text PDFCRISPR-Cas9-mediated genome editing delivered by a single AAV9 vector inhibits HSV-1 reactivation in a latent rabbit keratitis model.
Mol Ther Methods Clin Dev
September 2024
Excision BioTherapeutics Inc, Watertown, MA, USA.
Herpes simples virus 1 (HSV-1) keratitis is a major cause of blindness globally. During primary infection, HSV-1 travels to the trigeminal ganglia and establishes lifelong latency. Although some treatments can reduce symptom severity and recurrence, there is no cure for HSV-1 keratitis.
View Article and Find Full Text PDFDetection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling.
Immun Ageing
November 2024
Centre for Intelligent Healthcare, Coventry University, Priory Street, COVENTRY, CV1 5FB, Conventry, UK.
Article Synopsis
- Immune function declines with age, making it difficult to identify individuals at risk for immune-related issues, especially those with reactivated latent viral infections.
- The study focused on detecting certain human herpes viruses in urine as a potential way to identify immune-compromised individuals, particularly using T cell receptor excision circle (TREC) data as an indicator.
- While no clear one-to-one correlation was found between TREC values and individual viruses, a significant link was observed for males; specifically, low TREC values correlated with the detection of three or more different herpes viruses, suggesting declining immune function.
Cytomegalovirus Infections in Hematopoietic Stem Cell Transplant: Moving Beyond Molecular Diagnostics to Immunodiagnostics.
Diagnostics (Basel)
November 2024
College of Nursing and Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.
Human CMV, regularly reactivated by simple triggers, results in asymptomatic viral shedding, powerful cellular immune responses, and memory inflation. Immunocompetent individuals benefit from a robust immune response, which aids in viral management without causing clinically significant illness; however, immunodeficient individuals are always at a higher risk of CMV reactivation and disease. Hematopoietic stem cell transplant (HSCT) recipients are consistently at higher risk of CMV reactivation and clinically significant CMV illness due to primary disease, immunosuppression, and graft vs.
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