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Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review.
Inflammopharmacology
January 2025
Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India.
Nuclear factor kappa B (NF-kB) is a kind of transcription factor which resides in cytoplasm of each cell and on activation, it translocates to the nucleus. It is activated by a many inducible agents including endotoxins, inflammatory stimuli, carcinogens, pathogens, nicotine, and tumour promoters, etc. NF-kB is activated by canonical and non-canonical signalling pathways which has different signalling compounds and its biological functions.
View Article and Find Full Text PDFMetabolomic Analysis of Nicotine-Induced Metabolic Disruptions and Their Amelioration by Resveratrol.
J Biochem Mol Toxicol
January 2025
Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
This study investigates the metabolic disruptions caused by nicotine (NIC) exposure, with a particular focus on amino acid and lipid metabolism, and evaluates resveratrol (RSV) as a potential protective agent. Mice were divided into four groups: control (CON), NIC-exposed, NIC + RSV-treated, and RSV-only. NIC exposure resulted in significant weight loss, elevated glucose levels, altered lipid profiles, and organ damage, particularly in the liver and kidneys.
View Article and Find Full Text PDFExamining Bi-directional links between distinct affect states and tobacco lapse during a cessation attempt.
Drug Alcohol Depend
February 2025
Center for Health Outcomes and Population Equity (HOPE), Huntsman Cancer Institute and the University of Utah, United States; Department of Population Health Sciences, University of Utah, United States.
Background: Theoretical models of addiction highlight the bi-directional links of certain distinct affect states and tobacco lapse, but to date, few studies have examined bi-directional associations, instead examining associations with global affect measures (e.g., negative affect versus feelings of guilt).
View Article and Find Full Text PDFMelatonin prevents nicotine-induced hepatotoxicity by modulating apoptosis and histopathological changes in rats.
Pol J Vet Sci
December 2024
Technology and Research Research & Development Center (MARGEM), Hatay Mustafa Kemal University, Hatay, Turkey.
Nicotine, the main toxic component of tobacco, directly or indirectly causes adverse effects on the liver metabolism. Melatonin, secreted by the pineal gland, has anti-apoptotic activity as well as antioxidant activity. The aim of this study was to reveal the antiapoptotic effects of melatonin in rats with experimentally induced chronic liver damage with nicotine.
View Article and Find Full Text PDFFlavored E-Cigarette Sales Restrictions and Young Adult Tobacco Use.
JAMA Health Forum
December 2024
Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut.
Importance: More than one-quarter of US residents live in states or localities that restrict sales of flavored electronic nicotine delivery systems (ENDS), often as a means to reduce youth vaping. Yet, how these policies affect young adult vaping and smoking remains unclear.
Objective: To estimate the effects of ENDS flavor restrictions on ENDS use and cigarette smoking among young adults (age 18-29 years) in the US.
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