AI Article Synopsis
- The study aimed to assess how acute pulmonary tuberculosis (PTB) and its treatment affect liver enzyme levels (AST, ALT, GGT) without liver toxicity.
- During the study of 40 adults with active PTB, only one participant experienced a mild adverse drug reaction while taking anti-TB medication.
- Significant changes were observed in liver enzyme levels, with GGT decreasing and AST/ALT increasing, indicating improvements in oxidative stress over the first two months of treatment.
Article Abstract
Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods. A prospective followup of 40 adults (21 males; mean age of 34.7 ± 5.8 years) with active PTB on initial phase and continuation phase anti-TB. Results. Only 3% (n = 1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0-day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352232 | PMC |
| http://dx.doi.org/10.1155/2012/465634 | DOI Listing |
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