Cancer is a major burden worldwide but there are marked geographical variations in frequency and incidence overall. The aim of this study was to find the frequency and distribution of commonly occurring cancers in Kashmir, with particular emphasis on urinary bladder cancer. A total of 4,407 cases of histologically confirmed new cancer cases were registered at the Medical Records Department (MRD) of SKIMS from a period between January, 2005 and April 2010. Among 4407 cancers, 2,457 (55.7 %) were men and 1,950 (44.3 %) were women. Stomach cancer is the leading one with an average frequency of 19.2 % followed by esophagus and lung as 16.5 % and 14.6 %, respectively. Stomach (23 %) and lung (21 %) are the leading cancers in men while as esophageal cancer tops (18.3 %) in women followed by breast cancer (16.6 %). This distribution of cancer types is strikingly different from that in the rest of India where oropharyngeal cancer is most common form. Among urinogenital cancers, bladder cancer was observed to primarily affect Kashmiri population (5.9 %) followed by prostate cancer (2.1 %) and renal carcinoma (1.1 %). We conclude that Kashmir is a very high risk area of most commonly occurring cancers particularly cancers of gastrointestinal tract which comprise more than half the frequency of all the cancers.
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http://dx.doi.org/10.1007/s13277-012-0418-z | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Surface Chemistry Research Laboratory, Faculty of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Combination therapy, which involves using multiple therapeutic modalities simultaneously or sequentially, has become a cornerstone of modern cancer treatment. Graphene-based nanomaterials (GBNs) have emerged as versatile platforms for drug delivery, gene therapy, and photothermal therapy. These materials enable a synergistic approach, improving the efficacy of treatments while reducing side effects.
View Article and Find Full Text PDFCancer Immunol Res
January 2025
Sun Yat-sen University, Guangzhou, China.
Despite the pivotal role of cytotoxic T lymphocytes (CTLs) in anti-tumor immunity, a substantial proportion of CTL-rich hepatocellular carcinoma (HCC) patients experience early relapse or immunotherapy resistance. However, spatial immune variations impacting the heterogeneous clinical outcomes of CTL-rich HCCs remain poorly understood. Here, we compared the single-cell and spatial landscapes of 20 CTL-rich HCCs with distinct prognoses using multiplexed in situ staining and validated the prognostic value of myeloid spatial patterns in a cohort of 386 patients.
View Article and Find Full Text PDFJAMA Ophthalmol
January 2025
Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland.
JAMA Otolaryngol Head Neck Surg
January 2025
Department of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.
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