Poly(L-aspartic acid) derivative soluble in a volatile organic solvent for biomedical application.

Colloids Surf B Biointerfaces

Division of Biotechnology, The Catholic University of Korea, Wonmi-gu, Bucheon-si, Gyeonggi-do, Republic of Korea.

Published: September 2012

In order to develop a novel functional poly(L-amino acid) that can dissolve in volatile organic solvents, we prepared poly[L-aspartic acid-g-(3-diethylaminopropyl)]-b-poly(ethylene glycol) [poly(L-Asp-g-DEAP)-b-PEG] via the conjugation of 3-diethylaminopropyl (DEAP) to carboxylate groups of poly(L-Asp) (M(n) 4 K)-b-PEG (M(n) 2 K). This poly(L-aspartic acid) derivative evidenced a relatively high solubility in volatile organic solvents such as dichloromethane, chloroform, and acetone. We fabricated a model nanostructure (i.e., polymeric micelle) using poly(L-Asp-g-DEAP)-b-PEG by the film rehydration method, which involves the simple removal of the volatile organic solvent (dichloromethane) used to dissolve polymer, reducing concerns about organic solvents remaining in a nano-sized particle. Interestingly, this micelle showed the pH-stimulated release of encapsulated model drug [i.e., doxorubicin (DOX)] due to the protonation of DEAP according to the pH of the solution. We expect that this poly(L-aspartic acid) derivative promises to provide pharmaceutical potential for constituting a new stimuli-sensitive drug carrier for various drug molecules.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2012.03.024DOI Listing

Publication Analysis

Top Keywords

volatile organic
16
polyl-aspartic acid
12
acid derivative
12
organic solvents
12
organic solvent
8
organic
5
derivative soluble
4
volatile
4
soluble volatile
4
solvent biomedical
4

Similar Publications

Volatile oils (VOs), synonymously termed essential oils (EOs), are highly hydrophobic liquids obtained from aromatic plants, containing diverse organic compounds for example terpenes and terpenoids. These oils exhibit significant neuroprotective properties, containing antioxidant, anti-inflammatory, anti-apoptotic, glutamate activation, cholinesterase inhibitory action, and anti-protein aggregatory action, making them potential therapeutic agents in managing neurodegenerative diseases (NDs). VOs regulate glutamate activation, enhance synaptic plasticity, and inhibit oxidative stress through the stimulation of antioxidant enzymes.

View Article and Find Full Text PDF

Plants respond to attacks by insects by releasing herbivore-induced plant volatiles (HIPVs), which are known to influence the behavior of natural enemies, conspecific and heterospecific insects. However, little is known about how HIPVs induced by one insect species influence the behavior of an allospecific insect species, particularly if these insects belong to different feeding guilds. Here, using the interaction of two co-occurring insects with different feeding guilds - Bemisia tabaci (a sap sucking insect) and Tuta absoluta (a leaf mining insect) - on potato plants, we report that T.

View Article and Find Full Text PDF

Insights into the adsorption mechanisms of VOCs molecules on non-oxidized and oxidized SnO (110) monolayer: DFT analysis.

J Mol Model

January 2025

Laboratory of Nanostructures and Advanced Materials, Mechanics and Thermofluids, Faculty of Sciences and Technologies, Hassan II University of Casablanca, B.P 146, 20650, Mohammedia, Morocco.

Context: Designing efficient sensitive materials for the detection of volatile organic compounds (VOCs) such as ethanol, acetone, and benzene is stringent owing to the significant environmental and health risks induced by these compounds, in addition to their role as biomarkers for chronic diseases and food quality. This study investigates the adsorption mechanisms of VOC molecules (ethanol, acetone, and benzene) on both non-oxidized and oxidized SnO (110) monolayers and identifies the most suitable surface for gas sensing applications. For this, we examined structural properties, adsorption energies, density of states, gas responses, and recovery times.

View Article and Find Full Text PDF

The encapsulation of viologen derivatives in metal-organic frameworks (MOFs) to construct host-guest materials has been widely discussed owing to their distinctive spatial arrangement and physical/chemical properties. Herein, three new photochromic MOFs (NWM-1-3) have been successfully synthesized by 1,1,2,2-Tetra(4-carboxylphenyl)ethylene (H4TCPE) ligand as well as three different viologen derivatives based on host-guest strategy. Remarkably, NWM-1-3 exhibit a notable reversible photochromism change from yellow to green under 365 nm UV irradiation.

View Article and Find Full Text PDF

Increasing evidence demonstrates a robust link between environmental pollutants and allergic reactions, with air and indoor pollution exacerbating respiratory allergies and climate change intensifying seasonal allergies. Comprehensive action, including government regulations, public awareness, and individual efforts, is essential to mitigate pollution's impact on allergies and safeguard public health and ecological balance. Recent findings indicate a strong correlation between environmental pollutants and allergic reactions, with air pollution from vehicular emissions and industrial activities exacerbating respiratory allergies like asthma and allergic rhinitis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!