AI Article Synopsis
- Early treatment with triamcinolone right after oxygen exposure in a mouse model of retinopathy helped reduce harmful new blood vessel growth and levels of endostatin.* -
- Delayed treatment (3 days after oxygen exposure) effectively restricted abnormal blood vessel sprouting while still allowing normal retinal blood vessel development.* -
- The treatment outcomes were observed only in the eyes that received the therapy, meaning the effects were not seen in the untreated eyes.*
Article Abstract
In the murine model of oxygen-induced retinopathy of prematurity, early treatment (right after oxygen exposure) with triamcinolone reduced neovascularization and subsequently endostatin presence. Late treatment (3 days after oxygen exposure) limited pathological vascular sprouting, not interfering with normal vascularization of the retina. The effects remained unilateral in the treated eyes.
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| http://dx.doi.org/10.1016/j.exer.2012.04.017 | DOI Listing |
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