Morphology of uterine ligaments and the vaginal mucosa has been examined in 61 patients with uterine prolapse in order to provide guidelines for an optimum management with respect to tissue functional status. Specimens were obtained intraoperatively and examined in a usual microscope and a S-570 Hitachi scanning electron microscope (Japan). The study suggests that morphologic evaluation of the vaginal walls and uterine ligaments provides an exact measure of tissue status, offering an optimum choice of treatment in these patients.
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December 2024
Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
In order to plan and facilitate the culture of personalized / precision medicine in medical practices within any healthcare institution, it is requisite for healthcare professionals like clinicians to have a clear understanding and approach towards the practices of personalized genetic testing. This nationwide cross-sectional study aimed to measure the perceptions and knowledge of clinicians towards personalized genetic testing and assess their current practices of personalized genetic testing in clinical settings through an online self-administered questionnaire in Saudi Arabia. The results of the study revealed that almost two-fifths of participants were responsible for ordering genetic tests directly (39.
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December 2024
Health Services Research and Pharmacoepidemiology Unit, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Avenida Cataluña, 21, 46020, Valencia, Spain.
Improvement of post-stroke outcomes relies on patient adherence and appropriate therapy maintenance by physicians. However, comprehensive evaluation of these factors is often overlooked. This study assesses secondary stroke prevention by differentiating patient adherence to antithrombotic treatments (ATT) from physician-initiated interruptions or switches.
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December 2024
Pharmacy Department, Hospices Civils de Lyon, Hôpital E. Herriot, Plateforme FRIPHARM, 69437, Lyon, France.
Phage therapy uses viruses (phages) against antibiotic resistance. Tailoring treatments to specific patient strains requires stocks of various highly concentrated purified phages. It, therefore, faces challenges: titration duration and specificity to a phage/bacteria couple; purification affecting stability; and highly concentrated suspensions tending to aggregate.
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December 2024
Department of Medical Device Development, Seoul National University College of Medicine, Seoul, Republic of Korea.
Vertebral collapse (VC) following osteoporotic vertebral compression fracture (OVCF) often requires aggressive treatment, necessitating an accurate prediction for early intervention. This study aimed to develop a predictive model leveraging deep neural networks to predict VC progression after OVCF using magnetic resonance imaging (MRI) and clinical data. Among 245 enrolled patients with acute OVCF, data from 200 patients were used for the development dataset, and data from 45 patients were used for the test dataset.
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December 2024
Department of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang city, Jiangxi province, China.
P2X7 receptor (P2X7R) plays a role in regulating tumor progression, but it is unclear whether P2X7R affects the pathological characteristics of patients with gastric cancer and the activity of gastric cancer cells. Therefore, this study preliminarily investigated the relationship between P2X7R and clinicopathological features of patients with gastric cancer, and further explored the effect of P2X7R on the proliferation, migration and invasion of gastric cancer cells through functional experiments. The results showed that P2X7R was highly expressed in gastric cancer tissues and gastric cancer cells.
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