The efficiency of modern immunoactive preparation cycloferon at coplex therapy of the patients with nonalcoholic steatohepatitis (NASH) combined with irritable bowel syndrome (IBS). It was set that before treatment took place devition of immune homeostasis such as cellular immunity and serum interferon activity. Application of cycloferon provided to regress of clinical symptoms of NASH, combined with IBS and normalization of immune indexes.

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