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Differential regulation of KCC2 and NKCC1 expression by zolpidem in CA1 and CA3 hippocampal subregions of the lithium-pilocarpine status epilepticus rat model.
Exp Anim
January 2025
Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia.
Status epilepticus is linked to cognitive decline due to damage to the hippocampus, a key structure involved in cognition. The hippocampus's high vulnerability to epilepsy-related damage is the main reason for this impairment. Convulsive seizures, such as those observed in status epilepticus, can cause various hippocampal pathologies, including inflammation, abnormal neurogenesis, and neuronal death.
View Article and Find Full Text PDFZ hypnotics in the management of narcolepsy: a case series.
J Clin Sleep Med
December 2024
Sleep Disorders & Research Center, Department of Sleep Medicine, Henry Ford Health System, Detroit, MI.
Study Objectives: Here we report our experience treating patients with narcolepsy using benzodiazepine receptor agonists (BzRA), zolpidem (Zol) or eszopiclone (Esz) taken at bedtime for both excessive daytime sleepiness (EDS) and cataplexy.
Methods: We reviewed the medical records of 53 patients diagnosed with narcolepsy, between 2002 and 2023. Twenty-three patients, 8 with type1 (NT1), 13 with type 2 (NT2) and 2 with secondary narcolepsy, were treated with BzRA's (20 Zol and 3 Esz).
A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.
Explor Res Clin Soc Pharm
December 2024
College of Pharmacy, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- * A scoping review examined driving performance assessments related to BZRA use, analyzing 183 studies that featured various drugs, with zopiclone being the most researched.
- * Results showed that a significant number of studies found impairment in driving performance, with an emphasis on using certain measures like the Standard Deviation of Lateral Position (SDLP) in experimental settings, and biological detection methods in observational studies.
Alternative treatment in adolescent with anti-NMDA receptor encephalitis catatonia.
Neurocase
December 2024
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Article Synopsis
- An adolescent with ANMDAE and catatonia was treated with zolpidem after traditional treatments like benzodiazepines and ECT failed.
- ANMDAE presents with neuropsychiatric symptoms, including memory issues, seizures, and catatonia, which can lead to serious medical complications.
- Current guidelines offer limited options for treating catatonia in young patients who don't respond to standard treatments, and zolpidem may be a viable alternative.
Assessment of Potential Drug-Drug Interactions of Psycholeptics and Antidepressants in Outpatient Settings.
Pharmacy (Basel)
November 2024
Department of Clinical Pharmacy, University Hospital Dubrava, 10 000 Zagreb, Croatia.
Article Synopsis
- - Mental health issues are becoming more prevalent, necessitating careful management of psychotropic medications in outpatient settings to prevent potentially harmful drug interactions.
- - A study analyzed 492 outpatient cases, revealing an average of 1.64 prescribed psychotropic drugs and an alarming 2.2 potential drug-drug interactions (pDDIs) per patient, with about 47.6% involving psychotropics.
- - Younger patients (under 65) were found to receive more psychotropic medications, and key drugs involved in interactions included benzodiazepines, promazine, and zolpidem, highlighting the need for pharmacists to intervene and enhance patient safety.
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