A robust, high-sensitivity stealth probe for peptidases.

Chem Commun (Camb)

Laboratoire de Chimie, CNRS, École Normale Supérieure de Lyon, 46 Allée d'Italie, F-69364 Lyon, France.

Published: June 2012

AI Article Synopsis

Article Abstract

A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off-ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.

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Source
http://dx.doi.org/10.1039/c2cc32227gDOI Listing

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