AI Article Synopsis
- Recent PET studies show that lower levels of dopamine D2/3 receptors in the striatum are linked to higher impulsivity in healthy adults, but impulsivity is complex and varies in its components.
- The research investigated how limbic striatal D2/3 receptor levels relate to specific types of impulsivity—attentional, motor, and non-planning—through the Barratt Impulsiveness Scale in 23 healthy participants.
- Results indicated a significant connection between non-planning impulsivity (lack of foresight) and D2/3 receptor availability, especially after excluding those who may have manipulated their responses, suggesting that different aspects of impulsivity may have unique neurochemical influences.
Article Abstract
Positron emission tomography (PET) studies have reported an association between reduced striatal dopamine D2/3 receptor availability and higher scores on self-report measures of trait impulsivity in healthy adults. However, impulsivity is a multi-faceted construct, and it is unclear which aspect(s) of impulsivity might be driving these associations. The current study aimed to investigate the relationship between limbic (ventral) striatal D2/3 receptor availability and individual components of impulsivity (attentional, motor and non-planning) using the Barratt Impulsiveness Scale (BIS-11) and [(11)C]raclopride PET in 23 healthy volunteers. A partial correlational analysis showed a significant association between non-planning impulsiveness (lack of forethought or 'futuring') and limbic D2/3 receptor availability, which was only apparent after the exclusion of potential dissimulators (indexed by high scores on impression management). Our findings suggest that non-planning impulsiveness is associated with individual variation in limbic striatal D2/3 receptor availability and that different facets of impulsivity may have specific neurochemical correlates. Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function.
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| http://dx.doi.org/10.1016/j.pscychresns.2011.09.011 | DOI Listing |
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