Antinociceptive effects of galanin in the nucleus accumbens of rats.

Neurosci Lett

Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.

Published: June 2012

AI Article Synopsis

  • Galanin plays a significant role in pain regulation (nociception) in rats, particularly in the nucleus accumbens (NAc).
  • Injections of galanin into the NAc increase the time it takes for rats to react to painful stimuli, showing a dose-dependent relationship.
  • The antinociceptive effects of galanin can be blocked by a specific antagonist, indicating that galanin receptors are crucial for mediating these pain-relief effects.

Article Abstract

It has been demonstrated that galanin plays important roles in the modulation of nociceptive information in rats. The present study is performed to investigate the regulating role of galanin in nociception in the nucleus accumbens (NAc) of rats. Intra-NAc administration of galanin induces dose-dependent increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. Furthermore, the galanin-induced antinociceptive effects are blocked by following intra-NAc injection of the galanin receptor antagonist galantide. The results demonstrate that galanin induces antinociceptive effects in the NAc of rats, and galanin receptors are involved in the galanin-induced antinociception effects.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2012.05.027DOI Listing

Publication Analysis

Top Keywords

antinociceptive effects
12
nucleus accumbens
8
nac rats
8
galanin induces
8
galanin
7
rats
5
effects galanin
4
galanin nucleus
4
accumbens rats
4
rats demonstrated
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!