Few studies have been conducted on physical activity (PA) in older caregivers, a population at risk for mental and physical decline. To assess and compare PA, PA preferences, psychosocial determinants of PA, and mental health indicators between older non-exercising caregivers and non-caregivers. Caregivers (N = 24) and non-caregivers (N = 48) completed questionnaires and wore an accelerometer for 7 consecutive days. Few significant differences were noted in objectively measured or subjectively reported PA between caregivers and non-caregivers. Non-caregivers reported greater social support to exercise from family members. Caregivers reported significantly greater anxiety, depression, stress, and negative health symptoms. Caregivers were significantly more likely to prefer exercise in 10-min bouts. Caregivers are in need of interventions to increase PA and health. Efforts to help caregivers participate in multiple shorter bouts of exercise during the day could be more effective than recommending one continuous 30-minute bout.

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