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Vitrectomy for diabetic retinopathy: A review of indications, techniques, outcomes, and complications.
Taiwan J Ophthalmol
January 2024
Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Anant Bajaj Retina Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Diabetic retinopathy is one of the most severe forms of retinopathy and a leading cause of blindness all over the world. Of a greater concern is proliferative diabetic retinopathy which leads to vitreous haemorrhage and tractional retinal detachment in such cases. A majority of these cases require a surgical intervention to improve vision and prevent further vision loss.
View Article and Find Full Text PDFThe potential of serum elabela levels as a marker of diabetic retinopathy: results from a pilot cross-sectional study.
PeerJ
January 2025
Department of Biochemistry, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey.
Background: The aim of this study is to examine the relationship between elabela (ELA), a recently identified peptide also known as Toddler and Apela, and diabetic retinopathy (DR). ELA, produced in various tissues, acts as a natural ligand for the apelin receptor (APJ). Upon reviewing the existing literature, only one study was found investigating ELA, one of the APJ ligands, in the pathogenesis of DR.
View Article and Find Full Text PDFmiRNAs, piRNAs, and lncRNAs: A Triad of Non-Coding RNAs Regulating The Neurovascular Unit in Diabetic Retinopathy And Their Therapeutic Potentials.
Exp Eye Res
January 2025
Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, 605 014, India. Electronic address:
Diabetic Retinopathy (DR), a leading complication of diabetes mellitus, has long been considered as a microvascular disease of the retina. However, recent evidence suggests that DR is a neurovascular disease, characterized by the degeneration of retinal neural tissue and microvascular abnormalities encompassing ischemia, neovascularization, and blood-retinal barrier breakdown, ultimately leading to blindness. The intricate relationship between the retina and vascular cells constitutes a neurovascular unit, a multi-cellular framework of retinal neurons, glial cells, immune cells, and vascular cells, which facilitates neurovascular coupling, linking neuronal activity to blood flow.
View Article and Find Full Text PDFSREBF1 facilitates pathological retinal neovascularization by reprogramming the fatty acid metabolism of endothelial cells.
Exp Eye Res
January 2025
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder that critically affects the visual development of premature infants, potentially leading to irreversible vision loss or even blindness. Despite its significance, the underlying mechanisms of this disease remain insufficiently understood. In this study, we utilized the oxygen-induced retinopathy (OIR) mouse model and conducted endothelial functional assays to explore the role of Sterol Regulatory Element-Binding Protein 1 (SREBF1) in ROP pathogenesis.
View Article and Find Full Text PDFFaster referral and surgical intervention for rhegmatogenous retinal detachment during COVID-19: a comparison of pre- and during-pandemic cases.
Sci Rep
January 2025
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study investigated how the COVID-19 pandemic affected patients with rhegmatogenous retinal detachment (RRD) at Farabi Eye Hospital in Iran, comparing patients from before and during the pandemic.
- A total of 375 patients were analyzed, revealing that those referred during the pandemic had quicker referral and surgical wait times, but no significant changes in clinical characteristics or surgical outcomes.
- The use of general anesthesia increased during the pandemic period, prompting the need for further research into this trend.
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