AI Article Synopsis
- Recent studies suggest that CO(2) levels in the bladder could be linked to low blood flow conditions, prompting researchers to investigate this claim.
- Six beagle dogs were subjected to shock induced by E. coli lipopolysaccharide, measuring CO(2) levels in both the bladder and gastric tissues continuously.
- Findings revealed that bladder CO(2) levels were significantly lower than gastric CO(2) levels and showed poor correlation with hemodynamic measures, indicating that bladder CO(2) may not be a reliable indicator for identifying low perfusion states.
Article Abstract
Recent reports indicate the possible role of bladder CO(2) as a marker of low perfusion states. To test this hypothesis, shock was induced in six beagle dogs with 1 mg/kg of E. coli lipopolysaccharide, gastric CO(2) (CO(2)-G) was measured with a continuous monitor, and a pulmonary catheter was inserted in the bladder to measure CO(2) (CO(2)-B). Levels of CO(2)-B were found to be lower than those of CO(2)-G, with a mean difference of 36.8 mmHg (P < 0.001), and correlation between both measurements was poor (r(2) = 0.16). Even when the correlation between CO(2)-G and ΔCO(2)-G was narrow (r(2) = 0.86), this was not the case for the relationship between CO(2)-B and ΔCO(2)-B (r(2) = 0.29). Finally, the correlation between CO(2)-G and base deficit was good (r(2) = 0.45), which was not the case with the CO(2)-B correlation (r(2) = 0.03). In our experience, bladder CO(2) does not correlate to hemodynamic parameters and does not substitute gastric CO(2) for detection of low perfusion states.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349138 | PMC |
| http://dx.doi.org/10.1100/2012/360378 | DOI Listing |
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