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Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways.
Phytother Res
January 2025
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Atopic dermatitis (AD) is a common inflammatory dermatitis of the skin and poses therapeutic challenges due to the adverse reactions and high costs associated with available treatments. In Eastern Asian countries, a plethora of herbal remedies is extensively employed for the alleviation of AD. Many of these botanicals are renowned for their formidable anti-inflammatory properties, contributing to AD management.
View Article and Find Full Text PDFMechanistic insights into endosomal escape by sodium oleate-modified liposomes.
Beilstein J Nanotechnol
December 2024
Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung (ITB), Bandung 40132, Indonesia.
Endosomal entrapment significantly limits the efficacy of drug delivery systems. This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple-negative breast cancer cells. We aimed to elucidate the mechanistic role of sodium oleate in promoting endosomal escape and compared the performance of SO-Lipo with unmodified liposomes (Unmodified-Lipo) and Aurein 1.
View Article and Find Full Text PDFGas-flow activation of MOFs: unlocking efficient catalysis through dynamic bonding.
Chem Sci
December 2024
Department of Physics & Chemistry, DGIST Daegu 42988 Korea
Metal-organic frameworks (MOFs), characterized by dynamic metal-ligand coordination bonding, have pivotal roles in catalysis, gas storage, and separation processes, owing to their open metal sites (OMSs). These sites, however, are frequently occupied by Lewis-base solvent molecules, necessitating activation to expose the OMSs for practical applications. Traditional thermal activation methods involve harsh conditions, risking structural integrity.
View Article and Find Full Text PDFPractice, Experiences, and Facilitators of Simulation-Based Training During One Year of Implementation in 30 Hospitals in Tanzania.
SAGE Open Nurs
January 2025
Institute of Nursing and Health Promotion, Oslo Metropolitan University, Oslo, Norway.
Introduction: Enhancing the proficiency of healthcare workers (HCWs) in handling birth-related complications is crucial for reducing maternal and newborn morbidity and mortality. To achieve this, the Safer Births Bundle of Care offers a comprehensive set of innovative, simulation-based training interventions designed to strengthen the skills and competencies of HCWs working as skilled birth attendants.
Objective: To describe the use of low-dose, high-frequency simulation-based training, and the experiences of this usage among HCWs and stakeholders at facilities in Tanzania.
Evaluation of the Safety and Impact of Heat-Treated KM2 Fermentation on Gut Microbiome Architecture.
J Microbiol Biotechnol
December 2024
Department of Bio and Fermentation Convergence Technology, College of Science and Technology, Kookmin University, Seoul 02707, Republic of Korea.
Postbiotics, bioactive compounds from the fermentation process by probiotics, are gaining attention for their potential health benefits as safer alternatives to live probiotic microbes. is a well-studied probiotic species known for promoting gut health and immune modulation. However, the safety and effects of its postbiotic formulations on the gut microbiome structure remain less explored.
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