AI Article Synopsis
- The study aimed to find miRNA biomarkers that could help detect breast cancer early and identify minimal residual disease.
- Substantial increases in the levels of five specific miRNAs were found in breast tumors compared to healthy samples.
- However, further testing of these miRNAs and additional candidates did not support their potential as reliable biomarkers for breast cancer detection.
Article Abstract
To identify micro RNA (miRNA) biomarker candidates for early detection of breast cancer and detection of minimal residual breast cancer, we performed miRNA expression profiling in pooled RNA samples from breast tumors, and from bone marrow mononuclear cells, peripheral blood mononuclear cells and plasma from healthy controls. We found substantially higher levels of five miRNAs in the breast tumors compared to the normal samples. However, validation of these miRNA levels, and seven other candidates selected from the literature, in individual samples from healthy controls and patients with non-metastatic breast cancer did not suggest further examination of their biomarker potential.
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| http://dx.doi.org/10.3109/1354750X.2012.686061 | DOI Listing |
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