Objective: To explore the spatial distribution and pattern of advanced schistosomiasis in Anxiang County so as to provide the evidence for improving advanced schistosomiasis control.
Methods: Based on the geographic database of advanced schistosomiasis distribution at the village level in Anxiang County, Hunan Province, the spatial autocorrelation analysis and spatial scan statistics were applied to analyze the spatial characteristics of distribution of advanced schistosomiasis.
Results: The global Moran's I of prevalence rate of advanced schistosomiasis was 0.06 (P > 0.05) and there was no spatial auto-correlation as a whole. The local spatial auto-correlation analysis showed that there were 9 villages with statistically significant LISA value (P < 0.05), among which existed high-high, low-high and high-low types of auto-correlation model. The results of SaTScan statistics was the same as local spatial auto-correlation analysis and showed the existence of one cluster area.
Conclusions: There are local spatial auto-correlation and spatial aggregation of advanced schistosomiasis in Anxiang County. According to the distribution characteristics, we can assign resource more reasonably and control schistosomiasis more effectively.
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Eur J Med Chem
December 2024
Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123, Allschwil, Switzerland; University of Basel, P.O. Box CH-4003, Basel, Switzerland. Electronic address:
For over three decades, praziquantel (PZQ) has been the mainstay chemotherapy for prevention and treatment of schistosomiasis. The excessive use of PZQ, coupled with the lack of advanced drug candidates in the current anti-schistosomiasis drug development pipeline, emphasizes the genuine need for new drugs. In the current work, we investigated the antischistosomal potential of a new series of compounds derived from the privileged benzimidazole scaffold, which exhibited low micromolar IC potency in the range of 1.
View Article and Find Full Text PDFTrop Med Infect Dis
December 2024
Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife 50670-420, PE, Brazil.
The occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood in Brazil. The objective of this study was to estimate the seroprevalence of anti-HEV IgG in patients with SM and its association with the periportal fibrosis (PPF), assessed by serum markers and ultrasound criteria. This cross-sectional study was carried out in an endemic area in Pernambuco, Brazil, with schistosomal patients who underwent coproscopic survey.
View Article and Find Full Text PDFDiscov Med
December 2024
Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy.
In recent decades, technological advancements and scientific progress have significantly improved disease control strategies. However, the exclusive focus on these aspects often overlooks the crucial role of social and cultural factors. Local narratives, reflecting community traditions and beliefs, offer valuable insights that can influence the success of public health interventions.
View Article and Find Full Text PDFVaccine
July 2024
World Health Organization, Geneva, Switzerland.
BMC Infect Dis
November 2024
National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory On Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, Jiangsu, China.
Background: Schistosoma japonicum, the causative agent of schistosomiasis, heavily relies on its single intermediate host, the Oncomelania hupensis snail, for its life cycle. Controlling these snails effectively plays a pivotal role in curbing the transmission and prevalence of this disease. While prior research has extensively investigated the impact of environmental factors such as temperature and vegetation on snail survival, growth, and reproduction, the contribution of water physicochemical properties has been notably underexplored.
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