In the title compound, C(2)H(7)N(4)O(+)·BF(4) (-), inter-molecular N-H⋯O hydrogen bonds connect the cations into chains parallel to the c axis, with graph-set motif C(4). These chains are in turn connected into a three-dimensional network by inter-molecular N-H⋯F hydrogen bonds. The B-F distances distances in the anion are not equal.
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http://dx.doi.org/10.1107/S1600536812010665 | DOI Listing |
J Mater Chem B
January 2025
Department of Thoracic Cancer, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Intracellular delivery of proteins has attracted significant interest in biological research and cancer treatment, yet it continues to face challenges due to the lack of effective delivery approaches. Herein, we developed an efficient strategy cationic α-helical polypeptide-mediated anionic proprotein delivery. The protein was reversibly modified with adenosine triphosphate dynamic covalent chemistry to prepare an anionic proprotein (A-protein) with abundant phosphate groups.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming, 650091, P. R. China.
In recent years, visible light-induced ligand-to-metal charge transfer (LMCT) has emerged as an attractive approach for synthesizing a range of functionalized molecules. Compared to conventional photoredox reactions, photoinduced LMCT activation does not depend on redox potential and offers diverse reaction pathways, making it particularly suitable for the activation of inert bonds and the functional modification of complex organic molecules. This review highlights the indispensable role of photoinduced LMCT in synthetic chemistry, with a focus on recent advancements in LMCT-mediated hydrogen atom transfer (HAT), C-C bond cleavage, decarboxylative transformations, and radical ligand transfer (RLT) reactions.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Department of Chemistry - Ångström Laboratory, Uppsala University, SE-75120 Uppsala, Sweden.
Isonitrile-derivatized amino acids are emerging as highly effective infrared (IR) probes for investigating the structures and dynamics of hydrogen (H)-bonds. These probes enable the quantification of chemical exchange processes in solute-solvent complexes via two-dimensional IR spectroscopy and hold significant promise for site-specific dynamic studies within proteins. Despite their potential, theoretical models that elucidate the solvatochromism of isonitriles remain underdeveloped.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721 302, India.
The "catalytic triad" present at the active site of ribonuclease A (RNase A) is responsible for the cleavage of the 5'-phosphodiester bond; amino acid residues His12, Lys41 and His119 constituting this triad provide a positively charged environment at the physiological pH. Based on docking studies, 1,4,5-trisubstituted-carboxylated 1,2,3-triazoles (1,4,5-TTs) were identified as a new class of RNase A inhibitors. Therefore, two different groups of 1,4,5-TTs, functionalized with carboxylic acid groups, were synthesized by reacting pre functionalized butyne-1,4-diol derivatives with several aryl/alkyl azides under solvent and catalyst free conditions.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Shanghai Institute of Organic Chemistry, Materials Science, 345 lingling Road, 200032, Shanghai, CHINA.
Three-dimensional covalent organic frameworks (3D COFs), a class of highly porous crystalline polymers, have exhibited great potentials in many applications. However, the reported topologies of 3D COFs have been limited to high-symmetry crystal systems, which significantly hindered the development of such functional materials. Herein, we demonstrate the first construction of four highly crystalline orthorhombic 3D COFs with an unprecedented fmj topology, based on judiciously choosing rotatable monomers.
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