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The 2024 APLAR Consensus on the Management of Lupus Nephritis.
Int J Rheum Dis
January 2025
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
The APLAR has published a set of recommendations on the management of systemic lupus erythematosus (SLE) in 2021. The current consensus paper supplements and updates specifically the treatment of lupus nephritis (LN) according to two rounds of Delphi exercise from members of the APLAR SLE special interest group, invited nephrologists, histopathologists, and lupus nephritis patients. For initial treatment of LN, we recommend a combination of glucocorticoids (GCs) with cyclophosphamide (CYC), mycophenolate mofetil (MMF), or the calcineurin inhibitors (CNIs) as first-line options.
View Article and Find Full Text PDFSARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy.
Front Immunol
January 2025
Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.
Introduction: Multiple myeloma (MM) is an uncontrolled plasma cell proliferation in the bone marrow, leading to immune dysregulation with impaired humoral immune responses. Conversely, cellular-based responses play a vital role in MM patients. However, the extent and duration of cellular-induced protection remain unclear to date.
View Article and Find Full Text PDFDistribution characteristics and analysis of fungal aerosol concentration and particle size in air-conditioned wards in Wuhan, China.
Ann Agric Environ Med
December 2024
School of Biomedical Engineering and Imaging, Hubei University of Science and Technology, Hubei, China.
Fungal contamination in the air of hospital wards can affect the health of medical staff, patients, and caregivers. Through systematic analysis of the concentration, types, and particle size distribution characteristics of fungi in the air of wards in Wuhan, China, in 2023, it was found that there was no significant correlation between the concentration of fungi in the air of wards and the disease type and personnel density. The main influencing factors were temperature, humidity, and seasonal changes.
View Article and Find Full Text PDFCombination of Compound Kushen injection with first-line treatment versus first-line treatment alone for advanced colorectal cancer: a study protocol for a multicenter, openlabel, randomized controlled trial.
BMC Complement Med Ther
December 2024
Oncology Department, Guang'anmen Hospital, China, Academy of Chinese Medical Sciences, Beixian Pavilion, No.5, Xicheng District, Beijing, China.
Article Synopsis
- The study focuses on assessing the effectiveness and safety of Compound Kushen Injection (CKI) when used alongside first-line treatments for advanced colorectal cancer (CRC), as current therapies yield limited results.
- Participants will be randomly assigned to either a control or treatment group, with both groups receiving standard chemotherapy while the treatment group also receives CKI to determine its impact on progression-free survival and other health outcomes.
- This trial aims to provide valuable insights that could enhance treatment options for advanced CRC patients, making it a significant contribution to cancer research.
Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment.
Nat Commun
December 2024
Department of Ophthalmology, Columbia University, New York, NY, USA.
Best1 and Best2 are two members of the bestrophin family of anion channels critically involved in the prevention of retinal degeneration and maintenance of intraocular pressure, respectively. Here, we solved glutamate- and γ-aminobutyric acid (GABA)-bound Best2 structures, which delineate an intracellular glutamate binding site and an extracellular GABA binding site on Best2, respectively, identified extracellular GABA as a permeable activator of Best2, and elucidated the co-regulation of Best2 by glutamate, GABA and glutamine synthetase in vivo. We further identified multiple small molecules as activators of the bestrophin channels.
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