AI Article Synopsis
- The study developed a light-sensitive liquid crystalline matrix using a newly designed spiropyran molecule (SPL) that can be activated by light for drug delivery.
- The matrix changes its structure in response to light, shifting between two states which significantly affects how drugs are released.
- Unlike other similar compounds, SPL effectively alters the matrix, making it a promising option for creating systems that can deliver medication as needed.
Article Abstract
The purpose of this study was to create a light responsive nanostructured liquid crystalline matrix using a novel alkylated spiropyran photochromic molecule (spiropyran laurate, SPL) as a light activated drug delivery system. The liquid crystal matrix, prepared from phytantriol, responds reversibly to changes in photoisomerism of SPL on irradiation, switching between the bicontinuous cubic and the reversed hexagonal liquid crystal structures, a change previously shown to dramatically alter drug release rate. In contrast, the non-derivatized spiropyran and spirooxazine photochromic compounds do not sufficiently disrupt the matrix on isomerization to induce the phase change. Thus, novel alkylated spiropyran has the potential to be an effective agent for use in liquid crystalline systems for reversible 'on-demand' drug delivery applications.
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| http://dx.doi.org/10.1007/s13758-011-0003-9 | DOI Listing |
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