Background: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking.
Methods: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI).
Results: Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037).
Conclusions: Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000338276 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pain-related single nucleotide polymorphisms: association with lumbar spinal stenosis patient experience and non-surgical treatment outcomes.
Eur Spine J
June 2024
Department of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Purpose: Lumbar spinal stenosis (LSS) is common in our aging population resulting in pain and functional impairment. Recent advances in pain research have identified several single nucleotide polymorphisms (SNP) associated with inter-individual symptom and treatment response. The goal of the current study was to investigate the association of SNPs in Neuropeptide Y (NPY) and Catechol-O-methyltransferase (COMT) with pain, function, and treatment outcomes in Lumbar spinal stenosis (LSS) patients receiving non-surgical treatments.
View Article and Find Full Text PDFThe neuropeptide Y single-nucleotide polymorphism > moderates the effect of alcohol dependence on depression in male Chinese Han population.
Front Psychiatry
September 2022
School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Background: Previous studies suggest that alcohol dependence is associated with depression, however, the effect of alcohol dependence varies from individual to individual, which may be due to different genetic backgrounds. The interactions between alcohol dependence and different gene polymorphisms may finally shape the onset of depression. Neuropeptide Y (NPY), which can maintain homeostasis from high-stress stimulation, may protect individuals from the onset of depression.
View Article and Find Full Text PDFAssociation Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China.
Biomed Res Int
January 2022
School of Public Health, Guangdong Medical University, Dongguan 523808, China.
Objective: This study is aimed at analyzing the relationship between leptin (LEP) signaling pathway and type 2 diabetes mellitus (T2DM) and at providing support for molecular genetic research on the pathogenesis of T2DM in Chinese Han population.
Methods: A case-control study was designed, including 1092 cases with T2DM and 1092 healthy controls of Chinese Han origin recruited from ten hospitals in Guangdong Province, Southern China. Twenty-three single nucleotide polymorphisms (SNPs) of 15 genes in LEP signaling pathway were genotyped by SNPscan™ kit.
Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: A longitudinal birth cohort study.
Peptides
May 2021
Chair of Neuropsychopharmacology, Institute of Chemistry, University of Tartu, Tartu, Estonia. Electronic address:
Article Synopsis
- The study analyzed the relationship between four SNPs in the Neuropeptide Y (NPY) gene and various health indicators, including obesity, diet, physical activity, and metabolic measures over time.
- The research involved participants from the Estonian Children Personality Behaviour and Health Study at ages 15, 18, and 25, utilizing linear mixed-effects regression models.
- Key findings indicated that specific SNP variations were linked to changes in waist-to-hip ratio, body weight, dietary intake, blood pressure, and lipid levels as participants aged.
Article Synopsis
- The study investigates how the genetic variant rs16147 affects metabolic response and weight change in obese subjects following two different hypocaloric diets.
- Both diets led to improvements in adiposity, blood pressure, and leptin levels, but those with the A allele of rs16147 showed more significant decreases in insulin levels and insulin resistance (HOMA-IR) on the Mediterranean diet compared to the standard diet.
- The findings suggest that individuals carrying the A allele of rs16147 experience better metabolic outcomes from a hypocaloric Mediterranean diet than from a standard hypocaloric diet.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!