AI Article Synopsis
- A study was conducted on rats with focal ischemia to compare the neuroprotective effects of silymarin, piracetam, and protocatechuic acid ethyl ester (PCA).
- Both silymarin (200 mg/kg) and PCA showed significant improvements in behavioral, biochemical, and histopathological outcomes, and they reduced brain water content and infarct size.
- Silymarin was found to be more effective than both PCA and piracetam, particularly in restoring behavior and antioxidant levels during focal ischemia/reperfusion.
Article Abstract
Comparative neuroprotective potential of silymarin, piracetam and protocatechuic acid ethyl ester (PCA) was evaluated in focal ischemic rats. Various pharmacological, biochemical (lipid peroxidation, reduced glutathione, catalase, nitrite content, brain water content) and behavioural (memory impairment, motor control, neurological score) including infarct size and histopathological alterations were evaluated. Silymarin (200mg/kg) and PCA treatment significantly improved behavioural, biochemical and histopathological changes, and reduced water content and infarct size. However, piracetam only improved behavioural and histopathological changes, reduced water content and infarct size. The findings indicate that silymarin exhibits neuroprotective activity better than PCA and piracetam in focal ischemia/reperfusion reflected by its better restoration of behavioural and antioxidant profile.
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| http://dx.doi.org/10.1016/j.pbb.2012.05.004 | DOI Listing |
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