Zeolitic Imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle.

Dalton Trans

Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education Department of Chemistry, Northeast Normal University, Changchun, 130024, China.

Published: June 2012

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

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Source
http://dx.doi.org/10.1039/c2dt30357dDOI Listing

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