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Efficacy of Rectal Versus Oral Chloral Hydrate in Pediatric Auditory Brainstem Response: Randomized Controlled Trial.
OTO Open
September 2024
Department of Otorhinolaryngology, Faculty of Medicine Burapha University Chonburi Thailand.
Objective: To compare sedation success rates between rectal (RCH) and oral chloral hydrate (OCH) administration in children undergoing auditory brainstem response (ABR) testing and assess the incidence of adverse effects.
Study Design: Randomized controlled trial, performed between May 2023 and August 2023.
Setting: Ear, Nose, and Throat Outpatient Department at tertiary care hospital.
Efficacy and safety of rectal chloral hydrate for pediatric procedural sedation: A systematic review and meta-analysis.
Medicine (Baltimore)
August 2024
Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
Background: To evaluate the efficacy and safety of rectal chloral hydrate (CH) in pediatric procedural sedation.
Methods: Seven electronic databases and 3 clinical trials registry platforms were searched, and the deadline was August 2022. Randomized controlled trials evaluating the efficacy and safety of rectal CH in pediatric procedural sedation were included by 2 reviewers.
Needle-free pharmacological sedation techniques in paediatric patients for imaging procedures: a systematic review and meta-analysis.
Br J Anaesth
January 2023
Department of Anaesthesiology, Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address:
Article Synopsis
- This review analyzed sedation techniques for children aged 0-8 during MRI procedures, focusing specifically on needle-free methods.
- A total of 67 studies with over 22,000 participants were reviewed, revealing varying success rates for different sedation methods.
- Success rates ranged from 36% for rectal, oral, or intranasal midazolam to 99% for oral pentobarbital, highlighting significant differences in effectiveness among the sedation techniques used.
Chloral hydrate as a sedating agent for neurodiagnostic procedures in children.
Cochrane Database Syst Rev
August 2021
School of Medicine, Taylor's University, Subang Jaya, Selangor, Malaysia.
Background: This is an updated version of a Cochrane Review published in 2017. Paediatric neurodiagnostic investigations, including brain neuroimaging and electroencephalography (EEG), play an important role in the assessment of neurodevelopmental disorders. The use of an appropriate sedative agent is important to ensure the successful completion of the neurodiagnostic procedures, particularly in children, who are usually unable to remain still throughout the procedure.
View Article and Find Full Text PDFRectal chloral hydrate sedation for computed tomography in young children with head trauma.
Medicine (Baltimore)
March 2021
Department of Neurosurgery, Weifang People's Hospital, Weifang.
Children evaluated in the emergency department for head trauma often undergo computed tomography (CT), with some uncooperative children requiring pharmacological sedation. Chloral hydrate (CH) is a sedative that has been widely used, but its rectal use for child sedation after head trauma has rarely been studied. The objective of this study was to document the safety and efficacy of rectal CH sedation for cranial CT in young children.
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