Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats.

Neurosci Lett

Laboratory of Neurobiology, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.

Published: June 2012

AI Article Synopsis

  • CaMKII plays a vital role in the molecular pathways linked to drug addiction, particularly in the context of morphine-seeking behavior.
  • Studies demonstrated that altering CaMKII activity impacts how animals respond to drug use, with specific focus on the nucleus accumbens (NAc) shell in this research.
  • While blocking CaMKII activity after morphine self-administration didn't affect extinction, doing so before a reinstatement test successfully prevented relapse in morphine-seeking behaviors, highlighting CaMKII's importance in addiction relapse.

Article Abstract

The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) may be a core component in the common molecular pathways for drug addiction. Moreover, studies using animal models of drug addiction have demonstrated that changing CaMKII activity or expression influences animals' responses to the drugs of abuse. Here, we explored the roles of CaMKII in the nucleus accumbens (NAc) shell in the extinction and reinstatement of morphine-seeking behavior. Rats were trained to obtain intravenous morphine infusions through poking hole on a fixed-ratio one schedule. Selective CaMKII inhibitor myristoylated autocamtide-2-inhibitory peptide (myr-AIP) was injected into the NAc shell of rats after the acquisition of morphine self-administration (SA) or before the reinstatement test. The results demonstrated that injection of myr-AIP after acquisition of morphine SA did not influence morphine-seeking in the following extinction days and the number of days spent for reaching extinction criterion. However, pretreatment with myr-AIP before the reinstatement test blocked the reinstatement of morphine-seeking behavior induced by morphine-priming. Our results strongly indicate that CaMKII activity in the NAc shell is essential to the relapse to morphine-seeking.

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http://dx.doi.org/10.1016/j.neulet.2012.05.003DOI Listing

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