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Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats. | LitMetric

Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats.

Physiol Behav

Centro de Ciências Naturais e Exatas, Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Laboratório de Enzimologia Toxicológica, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Prédio 18, Sala 2208, 97105-900, Santa Maria, RS, Brazil.

Published: July 2012

AI Article Synopsis

  • Cigarette smoke is linked to reduced cognitive function, prompting research into how curcumin (Cur), an Indian spice, might help protect the brain from these effects.
  • The study involved treating rats with different doses of Cur and exposing them to cigarette smoke daily for 30 days to observe its impact on memory and brain enzyme activity.
  • Results showed that Cur could prevent certain cognitive and chemical changes caused by cigarette smoke, indicating it may improve memory by affecting the cholinergic system in the brain.

Article Abstract

Cigarette smoke, a widely spread habit, is associated with a decline in cognitive function and studies have demonstrated that curcumin (Cur), an Indian spice, possesses a strong neuroprotective potential. Considering the relevance of investigating dietary compounds this study aimed to investigate the effect of Cur on memory and acetylcholinesterase (AChE) activity in brain structures and blood of cigarette smoke-exposed rats. Male Wistar rats were treated with curcumin and cigarette smoke, once a day, 5 days each week, for 30 days. The experimental procedures were divided in two sets of experiments. In the first, the animals were divided into 4 groups: Vehicle (corn oil), Cur 12.5 mg/kg, Cur 25 mg/kg and Cur 50 mg/kg. In the second, the animals were divided into 5 groups: Vehicle (corn oil), Smoke, Smoke plus Cur 12.5 mg/kg, Smoke plus Cur 25 mg/kg and Smoke plus Cur 50 mg/kg. Treatment with Cur significantly prevented the decreased latency and cholinergic alterations in cigarette smoke-exposed rats. These AChE alterations could suggest a role in the memory impairment promoted by cigarette smoke-exposure and point toward the potential of Cur to modulate cholinergic neurotransmission and, consequently, improve cognition deficits induced by smoke. This study suggests that the dietary compound Cur may be involved in cholinergic system modulation and as a consequence exert an effect on learning and memory.

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Source
http://dx.doi.org/10.1016/j.physbeh.2012.05.001DOI Listing

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